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Genetic Link Between Alzheimer’s Disease and Type 2 Diabetes

Principal Investigator(s): 

The association between type 2 diabetes (T2D) and Alzheimer's disease (AD) is well established, however, the biologic mechanisms linking these two diseases together are unknown. One emerging etiologic link is the protein sorting pathway. This study is examining genetic variants in pathways linked to both T2D and AD. Completion of the project is expected to provide novel insights about the mechanisms of AD and the link between T2D and AD in order to suggest strategies for prevention, diagnosis, and therapy. This is especially important for AD, a disease for which there is currently no treatment that can delay or stop the deterioration of brain cells.