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Lorraine F. Meisner, PhD

  • Professor Emeritus, Population Health Sciences

Biography

Lorraine Meisner received her PhD in Genetics from the University of Chicago in 1966. She has been a faculty member at the University of Wisconsin-Madison since 1968.

Dr. Meisner's research centers around identification of genetic changes associated with neoplastic development, and evaluation of their significance. This specifically involves linking epidemiologic data to specific alterations identified by fluorescent in-situ hybridization (FISH) to identify and quantify genetic changes associated with malignant transformation. She is also involved in research to evaluate the causes and frequency of cytogenetic aberrations associated with abnormal somatic development resulting in birth defects.

Select Publications

Zilmer M, Harris C, Steiner D, and Meisner L. Use of Nonbreakpoint DNA Probes to Detect the t(X;18) in Interphase Cells From Synovial Sarcoma. Implications for Detection of Diagnostic Tumor Translocations. Am J Pathology 1998; 152: 1171-1177. (Monica Zilmer was a med student from Sweden who came to work with me for one year.)

Doyle G, Bourdeau-Heller J, Coulthard S, Meisner L, and Ross J. Amplification in Human Breast Cancer of a Gene Encoding a c-myc mRNA-binding Protein. Cancer Research 2000; 60: 2756-2759.

Billings SD, Meisner L, Cummings OW and Tejada E. Synovial Sarcoma of the Upper Digestive Tract: A Report of Two Cases With Demonstration of the X;18 Translocation by Fluorescence in Situ Hybridization. Modern Pathology 2000; 13: 68-76.

Doyle GA, Bourdeau-Heller JM, Coulthard S, Meisner L, and Ross J. Amplification in Human Breast Cancer of a Gene Encoding a c-myc mRNA-binding Protein. Cancer Research 2000; 60: 2756-2759.

Allen-Hoffmann BL, Schlosser SJ, Ivarie CA, Sattler CA, Meisner L, and O'Connor SL. Normal Growth and Differentiation in a Spontaneously Immortalized Near-Diploid Human Keratinocyte Cell Line, NIKS. J Invest Dermatol 2000; 114: 444-455.

Zilmer M, Harris C, Steiner S, and Meisner L. Use of Non-Specific DNA Probes to Detect Diagnostic Translocations Demonstrated by the t(X;18) in Synovial Sarcoma. Am J Pathology 1998; 152: 1171-1177.

Jacoby RF, Schlack S, Cole CE, Skarbek M, Harris C, and Meisner L. A Juvenile Polyposis Tumor Suppressor Locus at 10q22 is Deleted From Nonepithelial Cells in the Lamina Propria. Gastroenterology 1997; 112: 1398-1403.

Logrono R, Garcia-Lithgow C, Harris C, Kent M, and Meisner L. Heteropagus Conjoined Twins Due to Fusion of Two Embryos: Report and Review. Am J Medical Genetics 1997; 73: 239-243.

Xing W, Gilchrist K, Harris CP, Samson W, and Meisner L. FISH Detection of HER-2/neu Oncogene Amplifications in Early Onset Breast Cancer. Breast Cancer Research and Treatment 1997; 39: 203-212.