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Contact Corinne

Campus Address: 

Room 1007a WARF
610 Walnut Street
Madison, WI 53726

Campus Phone Number: 
(608) 265-5491

Corinne D. Engelman, MSPH, PhD

  • Associate Professor
  • Department of Population Health Sciences

Biography

Dr. Engelman earned her MS in Public Health (2002) and PhD in Epidemiology (2006) from the University of Colorado Health Sciences Center and has been a faculty member in Population Health Sciences at UW-Madison since 2007. Her research focuses on the study design and data analysis of genetic, demographic, socioeconomic, behavioral, physiological and environmental factors of complex diseases, including biomarkers and preclinical traits related to Alzheimer’s disease, and also vitamin D deficiency. Dr. Engelman’s group uses epidemiological, statistical, and bioinformatic approaches to analyze large-scale ‘omic data, including that from whole genome array genotyping; whole-genome sequencing; DNA methylation beadchip; and metabolomic, lipidomic, and proteomic mass spectrometry. Her research integrates ‘omic and questionnaire data to understand, predict, prevent, and/or treat health conditions. Dr. Engelman is especially interested in identifying interactions with modifiable factors (e.g., social, behavioral, and environmental) to inform precision medicine and health.

Courses Taught:

  • PHS 888: Public Health Genomics
  • PHS 849: Genetic Epidemiology

Affiliations/Associations

  • American Society of Human Genetics
  • International Genetic Epidemiology Soceity
  • International Society to Advance Alzheimer Research and Treatment

Recent Honors/Awards

  • Elected member of Delta Omega National Honor Society in Public Health, 2014
  • Population Health Outstanding Instructor Award, 2013
  • Outstanding Young Investigator in Alzheimer's Disease (selected by the Charleston Conference on Alzheimer's Disease Scientific Board), 2012

Select Publications

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD. Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s Disease. J Alzheimers Dis 2017; 55(2): 473-484. PMCID: PMC5123972.

Engelman CD, Greenwood CMT, Bailey JN, Cantor RM, Kent JW, Konig IR, Bermejo JL, Melton PE, Santorico SA, Schillert A, Wijsman EM, MacCluer JW, Almasy L. Genetic Analysis Workshop 19: Methods and Strategies for Analyzing Human Sequence and Gene Expression Data in Extended Families and Unrelated Individuals. BMC Proceedings 2016 Oct 18; 10(Suppl 7): 67-70. PMCID: PMC5133501.

Darst BF, Engelman CD. Transmission and Decorrelation Methods for Detecting Rare Variants Using Sequencing Data From Related Individuals. BMC Proceedings 2016 Oct 18; 10(Suppl 7): 203-207. PMCID: PMC5133523.

Sippy R, Kolesar JM, Darst BF, Engelman CD. Prioritization of Family Member Sequencing for the Detection of Rare Variants. BMC Proceedings 2016 Oct 18; 10(Suppl 7): 227-231. PMCID: PMC5133500.

Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, Hogan KJ, Mueller KD, Bendlin BB, Carlsson CM, Asthana S, Sager MA, Hermann BP, Johnson SC. Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer’s Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data. Arch Clin Neuropsychol 2016 May 8 (Epub ahead of print).

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC. Beta-Amyloid and Cognitive Decline in Late Middle Age: Findings from the Wisconsin Registry for Alzheimer’s Prevention Study. Alzheimers Dement 2016 Jul; 12(7): 805-14.

Millen AE, Meyers KJ, Liu Z, Engelman CD, Wallace RB, LeBlanc ES, Tinker LF, Iyengar SK, Robinson JG, Sarto GE, Mares JA. Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk. JAMA Ophthalmol 2015 Oct 1; 133(10): 1171-9. PMCID: PMC4841267.

Darst BF, Koscik RL, Hermann BP, La Rue A, Sager MA, Johnson SC, Engelman CD. Heritability of Cognitive Traits Among Siblings with a Parental History of Alzheimer’s Disease. J Alzheimers Dis 2015 Jan; 45(4): 1149-55. PMCID: PMC4398625.

Malecki KC, Engelman CD, Peppard PE, Nieto FJ, Grabow ML, Bernardinello M, Bailey E, Walsh MC, Lo J, Martinez-Donate A. The Wisconsin Assessment of the Social and Built Environment (WASABE). A Multi-dimensional Objective Audit Instrument for Examining Neighborhood Effects on Health. BMC Public Health 2014 Nov 13; 14: 1165. PMCID: PMC4289353.

Sung YJ, Korthauer KD, Swartz MD, Engelman CD. Methods for Collapsing Multiple Rare Variants in Whole Genome Sequence Data. Genet Epidemiol 2014 Aug; 38(S1): S13-20.

Yao C, Leng N, Weigel KA, Lee KE, Engelman CD, Meyers KJ. Prediction of Genetic Contributions to Complex Traits Using Whole Genome Sequencing Data. BMC Proceedings 2014 Jun; 8(Suppl 1): S68. PMCID: PMC4143683.

Bickeböller H, Bailey JN, Beyene J, Cantor RM, Cordell HJ, Culverhouse RC, Engelman CD, Fardo DW, Ghosh S, König IR, Lorenzo Bermejo J, Melton PE, Santorico SA, Satten GA, Sun L, Tintle NL, Ziegler A, MacCluer JW, Almasy L. Genetic Analysis Workshop 18: Methods and Strategies for Analyzing Human Sequence and Phenotype Data in Members of Extended Pedigrees. BMC Proceedings 2014 Jun; 8(Suppl 1): S1. PMCID: PMC4143625.

Engelman CD, Bo R, Zuelsdorff M, Steltenpohl H, Kirby T, Nieto FJ. Epidemiologic Study of the C-3 Epimer of 25-Hydroxyvitamin D3 in a Population-Based Sample. Clin Nutr 2014 Jun; 33(3): 421-5. PMCID: PMC3884039.

Engelman CD, Koscik RL, Jonaitis EM, Hermann BP, La Rue A, Sager MA. Investigation of TREM2 Variant in the Wisconsin Registry for Alzheimer’s Prevention. Neurobiology of Aging 2014 Jun; 35(6): 1252-4. PMCID: PMC3961539.

Bailey EJ, Engelman CD, Walsh MC, Bersch AJ, Martinez-Donate AP, Peppard PE, Nieto FJ, Malecki KC. Predictors of Discordance Between Perceived and Objective Neighborhood Data. Ann Epidemiol 2014 Mar; 24(3): 214-21. PMCID: PMC3947547.

Engelman CD. Towards Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect? Diabetes 2014 Feb; 63(2): 405-6. (Invited editorial).

Zuelsdorff ML, Engelman CD, Friedman EM, Koscik RL, Jonaitis EM, La Rue A, Sager MA. Stressful Events, Social Support, and Cognitive Function in Middle-Aged Adults with a Family History of Alzheimer’s Disease. J Aging Health 2013 Sep; 25(6): 944-59. PMCID: PMC3769466.

Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA. Interaction Between Two Cholesterol Metabolism Genes Influences Memory: Findings from the Wisconsin Registry for Alzheimer’s Prevention. J Alzheimers Dis 2013 Aug; 36(4): 749-57. PMCID: PMC3759032.

Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo, Jr RP, Truitt B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, LeBlanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE. Vitamin D Intake and Season Modify the Effects of the GC and CYP2R1 Genes on 25-Hydroxyvitamin D Concentrations. J Nutr 2013 Jan; 143(1): 17-26. PMCID: PMC3521459,