Room 1007a WARF
610 Walnut Street
Madison, WI 53726
Corinne D. Engelman, MSPH, PhD
- Associate Professor
Dr. Engelman is a genetic epidemiologist interested in complex diseases and quantitative traits of aging, such as Alzheimer's disease, cognitive function, vitamin D deficiency, type 2 diabetes, and insulin resistance. She is particularly interested in gene-gene and gene-environment interactions and methodologic approaches to studying the genetic contribution to complex phenotypes.
One major area of research is the genetic and non-genetic factors associated with vitamin D. Vitamin D deficiency is associated with many adverse health outcomes, including bone diseases, cancer, autoimmune diseases, infections, diabetes and the metabolic syndrome, hypertension, cardiovascular disease, and cognitive decline, making vitamin D an important health outcome of interest. Dr. Engelman is currently studying the genetic, demographic, behavioral, physiological, and environmental correlates of vitamin D levels in the blood and of the association between vitamin D and other health outcomes, such as blood pressure and lipid concentrations, in Caucasians from the Survey of the Health of Wisconsin (SHOW).
Dr. Engelman is also studying the genetic and non-genetic determinants of cognitive decline in the Wisconsin Registry for Alzheimer's Prevention (WRAP), a longitudinal cohort study of asymptomatic middle-aged adults enriched for a parental history of Alzheimer's disease. She is particularly interested in gene-gene and gene-environment interactions in four main pathways that may contribute to cognitive decline and risk for Alzheimer's: cholesterol metabolism, insulin resistance, inflammation, and vitamin D metabolism. Moreover, she is interested in the role that low frequency and rare genetic variants may play in cognitive decline and Alzheimer's.
- PHS 650: Special Topics: Public Health Genomics
- PHS 904: Special Topics in Epidemiology: Genetic Epidemiology
- PHS 904: Special Topics in Epidemiology: Analytic Methods in Genetic Epidemiology
- American Society of Human Genetics
- International Genetic Epidemiology Soceity
- International Society to Advance Alzheimer Research and Treatment
- Elected member of Delta Omega National Honor Society in Public Health, 2014
- Population Health Outstanding Instructor Award, 2013
- Outstanding Young Investigator in Alzheimer's Disease (selected by the Charleston Conference on Alzheimer's Disease Scientific Board), 2012
Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD. Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s Disease. J Alzheimers Dis 2017; 55(2): 473-484. PMCID: PMC5123972.
Engelman CD, Greenwood CMT, Bailey JN, Cantor RM, Kent JW, Konig IR, Bermejo JL, Melton PE, Santorico SA, Schillert A, Wijsman EM, MacCluer JW, Almasy L. Genetic Analysis Workshop 19: Methods and Strategies for Analyzing Human Sequence and Gene Expression Data in Extended Families and Unrelated Individuals. BMC Proceedings 2016 Oct 18; 10(Suppl 7): 67-70. PMCID: PMC5133501.
Darst BF, Engelman CD. Transmission and Decorrelation Methods for Detecting Rare Variants Using Sequencing Data From Related Individuals. BMC Proceedings 2016 Oct 18; 10(Suppl 7): 203-207. PMCID: PMC5133523.
Sippy R, Kolesar JM, Darst BF, Engelman CD. Prioritization of Family Member Sequencing for the Detection of Rare Variants. BMC Proceedings 2016 Oct 18; 10(Suppl 7): 227-231. PMCID: PMC5133500.
Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, Hogan KJ, Mueller KD, Bendlin BB, Carlsson CM, Asthana S, Sager MA, Hermann BP, Johnson SC. Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer’s Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data. Arch Clin Neuropsychol 2016 May 8 (Epub ahead of print).
Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC. Beta-Amyloid and Cognitive Decline in Late Middle Age: Findings from the Wisconsin Registry for Alzheimer’s Prevention Study. Alzheimers Dement 2016 Jul; 12(7): 805-14.
Millen AE, Meyers KJ, Liu Z, Engelman CD, Wallace RB, LeBlanc ES, Tinker LF, Iyengar SK, Robinson JG, Sarto GE, Mares JA. Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk. JAMA Ophthalmol 2015 Oct 1; 133(10): 1171-9. PMCID: PMC4841267.
Darst BF, Koscik RL, Hermann BP, La Rue A, Sager MA, Johnson SC, Engelman CD. Heritability of Cognitive Traits Among Siblings with a Parental History of Alzheimer’s Disease. J Alzheimers Dis 2015 Jan; 45(4): 1149-55. PMCID: PMC4398625.
Malecki KC, Engelman CD, Peppard PE, Nieto FJ, Grabow ML, Bernardinello M, Bailey E, Walsh MC, Lo J, Martinez-Donate A. The Wisconsin Assessment of the Social and Built Environment (WASABE). A Multi-dimensional Objective Audit Instrument for Examining Neighborhood Effects on Health. BMC Public Health 2014 Nov 13; 14: 1165. PMCID: PMC4289353.
Sung YJ, Korthauer KD, Swartz MD, Engelman CD. Methods for Collapsing Multiple Rare Variants in Whole Genome Sequence Data. Genet Epidemiol 2014 Aug; 38(S1): S13-20.
Yao C, Leng N, Weigel KA, Lee KE, Engelman CD, Meyers KJ. Prediction of Genetic Contributions to Complex Traits Using Whole Genome Sequencing Data. BMC Proceedings 2014 Jun; 8(Suppl 1): S68. PMCID: PMC4143683.
Bickeböller H, Bailey JN, Beyene J, Cantor RM, Cordell HJ, Culverhouse RC, Engelman CD, Fardo DW, Ghosh S, König IR, Lorenzo Bermejo J, Melton PE, Santorico SA, Satten GA, Sun L, Tintle NL, Ziegler A, MacCluer JW, Almasy L. Genetic Analysis Workshop 18: Methods and Strategies for Analyzing Human Sequence and Phenotype Data in Members of Extended Pedigrees. BMC Proceedings 2014 Jun; 8(Suppl 1): S1. PMCID: PMC4143625.
Engelman CD, Bo R, Zuelsdorff M, Steltenpohl H, Kirby T, Nieto FJ. Epidemiologic Study of the C-3 Epimer of 25-Hydroxyvitamin D3 in a Population-Based Sample. Clin Nutr 2014 Jun; 33(3): 421-5. PMCID: PMC3884039.
Engelman CD, Koscik RL, Jonaitis EM, Hermann BP, La Rue A, Sager MA. Investigation of TREM2 Variant in the Wisconsin Registry for Alzheimer’s Prevention. Neurobiology of Aging 2014 Jun; 35(6): 1252-4. PMCID: PMC3961539.
Bailey EJ, Engelman CD, Walsh MC, Bersch AJ, Martinez-Donate AP, Peppard PE, Nieto FJ, Malecki KC. Predictors of Discordance Between Perceived and Objective Neighborhood Data. Ann Epidemiol 2014 Mar; 24(3): 214-21. PMCID: PMC3947547.
Engelman CD. Towards Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect? Diabetes 2014 Feb; 63(2): 405-6. (Invited editorial).
Zuelsdorff ML, Engelman CD, Friedman EM, Koscik RL, Jonaitis EM, La Rue A, Sager MA. Stressful Events, Social Support, and Cognitive Function in Middle-Aged Adults with a Family History of Alzheimer’s Disease. J Aging Health 2013 Sep; 25(6): 944-59. PMCID: PMC3769466.
Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA. Interaction Between Two Cholesterol Metabolism Genes Influences Memory: Findings from the Wisconsin Registry for Alzheimer’s Prevention. J Alzheimers Dis 2013 Aug; 36(4): 749-57. PMCID: PMC3759032.
Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo, Jr RP, Truitt B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, LeBlanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE. Vitamin D Intake and Season Modify the Effects of the GC and CYP2R1 Genes on 25-Hydroxyvitamin D Concentrations. J Nutr 2013 Jan; 143(1): 17-26. PMCID: PMC3521459,